Johnson & Johnson’s potential coronavirus vaccine prevented severe sickness in a small group of Syrian golden hamsters, the corporate stated Thursday.
J&J researchers vaccinated hamsters with a single dose and uncovered the rodents to the virus 4 weeks later, the corporate stated.
J&J stated the vaccine elicited neutralizing antibodies in hamsters who obtained the vaccine, which the researchers imagine are vital to construct immunity to the virus. The hamsters additionally appeared to lose much less weight than hamsters that didn’t obtain the vaccine and didn’t have severe medical situations reminiscent of pneumonia and mortality. The outcomes were released on Thursday within the medical journal Nature Drugs.
“This preclinical examine additional confirms our confidence in our SARS-CoV-2 vaccine candidate,” stated Paul Stoffels, J & J’s chief scientific officer, in a press launch. “With our Section three trials scheduled to start this month, we stay dedicated to increasing our manufacturing and distribution capabilities to offer international entry to our SARS-CoV-2 vaccine candidate whether it is secure in people and may show efficient. “
The promising ends in hamsters don’t essentially imply that the vaccine provides the identical degree of safety in people. Nonetheless, J&J researchers famous that the outcomes are vital as Covid-19 is understood to trigger severe sickness in some individuals.
J&J is one in every of a number of corporations working to develop a vaccine in opposition to the coronavirus, which continues to unfold quickly around the globe. The corporate expects to start out a 60,000-person late-stage examine testing the vaccine this month. It will be the most important examine so far to check a coronavirus vaccine.
The US Division of Well being introduced on Aug. 5 that it had signed a contract with Janssen, J & J’s pharmaceutical subsidiary, value roughly $ 1 billion for 100 million doses of its vaccine. The deal offers the federal authorities the power to order a further 200 million cans announcement.
J&J stated it makes use of the identical expertise for its coronavirus vaccine because it does for its experimental Ebola vaccine made accessible to individuals within the Democratic Republic of the Congo. Genetic materials from the coronavirus is combed with a modified adenovirus, which is understood to trigger colds in people.
Members within the Section three examine might be randomly chosen to obtain a dose of the potential vaccine or a placebo in response to the main points of the examine, which might be used to find out whether or not the vaccine is secure and efficient. They’ve been adopted by researchers for greater than two years.
Thursday’s outcomes comply with knowledge launched in July that the J&J vaccine protected non-human primates in a preclinical examine.